AUTHORS NOTE: The background section will be uploaded with each post, so there will be no need to check back. If you have already read the background, feel free to scroll down to paragraph two. Recommended Readings: The Tides of Minds: Uncovering the Spectrum of Consciousness by David Gelernter
Background
Classic Hallucinogenic drugs are agonists of our serotonergic receptors. They are able to produce significant changes in the perceptions of those who consume them. Historically, some hallucinogens have been used in cultural rituals, spiritual ceremonies, and developmental rites of passage (Piotrowski, 2013). Common hallucinogens are Lysergic Acid Diethylamide (LSD), 3,4-methylenedioxymethamphetamine (MDMA), psilocybin (from mushrooms), mescaline (from peyote), and the potent dimethyltryptamine (DMT). The experience can be either pleasant or upsetting, and the duration of the experience varies from experience to experience and from substance to substance. Most of these substances have been illegal since the 1970s; however, they have regained interest among researchers for the treatment of different types of mental stress and mental disorders (Piotrowski, 2013). Personality can develop through the desire to change and the belief that change is possible. Then one can begin to perform the necessary new behaviors, which, over time, become habitual and lead to lasting personality change (Funder, 2016, p. 249). Spontaneous, lasting change seems to be rare, so it would be interesting if the temporary subjective change in a person’s perception would also change some aspects of a person’s personality. This review will examine the effects of psychedelics on personality, where personality refers to an individual’s characteristic patterns of thought, emotion, and behavior, together with the psychological mechanisms—hidden or not—behind those patterns. (Funder, 2016, p. 5).

Personality, psychopathology, life attitudes, and neuropsychological performance among ritual users of ayahuasca: a longitudinal study
Ayahuasca is an Amazonian psychoactive plant medicine containing the serotonergic agonist N,N-dimethyltryptamine (DMT). This psychedelic brew commonly contains the ayahuasca vine Banisteriopsis caapi, as well as monoamine oxidase-inhibiting alkaloids that make it orally active by using the Chacruna shrub Psychotria viridis, which has traditional use among Brazilian churches but has spread into North America and Europe. When used in these religious rituals, ayahuasca is used twice a month.
There were two different sample groups, both with separate controls. The first group of participants was taken from jungle communities. This group (n = 56) was sampled from Céu do Mapiá, a community of religious ayahuasca users within the Amazon rainforest. The estimated lifetime exposure to ayahuasca in this group was between 360 and 1080 times. The control group (n = 56) was recruited from the nearest community to Céu do Mapiá, Boca do Acre. Out of the 56 controls only 7 have ever had previous experience with ayahuasca. The second sample was taken from urban areas. The ayahuasca user group (n = 71) consisted of members from a religious group called Barquinha located in the city of Rio Branco, with an average lifetime exposure to ayahuasca of an estimated average of 360–1440 times. The urban control group (n = 59) was taken from the same city, with only four of the participants ever ingesting ayahuasca. The researchers took a total of ten separate measures ranging from socio-demographics, personality, psychopathology, and neuropsychological performance tasks associated with planning and memory. They also took three separate measures of life attitudes and psychosocial well-being.
Users of ayahuasca showed higher reward dependence and self-transcendence and lower harm avoidance and self-directedness. They also scored significantly lower on all the psychopathology measures, in terms of anxiety, depression, and obsessive-compulsive disorder. Furthermore, the ayahuasca users performed better on the neuropsychological performance tasks. Higher scores were also found on spiritual orientation, life purposefulness, and well-being. Interestingly, these findings were maintained one year later.
References
Bouso, J. C., González, D., Fondevilla, S., Cutchet, M., Fernández, X., Ribeiro Barbosa, P. C., & … Mazza, M. (2012). Personality, psychopathology, life attitudes and neuropsychological performance among ritual users of ayahuasca: a longitudinal study. Public Library of Science, 7(8) , 1-13. doi:10.1371/journal.pone.0042421
Carhart-Harris, R., Kaelen, M., Bolstridge, M., Williams, T., Williams, L., Underwood, R.,…Nutt, D. (2016). The paradoxical psychological effects of lysergic acid diethylamide (LSD). Psychological Medicine, 46(7), 1379-1390. doi:10.1017/S0033291715002901
Funder, D. (2016) The personality puzzle. W.W. Norton & Company.
Griffiths R. R., Johnson M. W., Richards W.A., Richards B. R., McCann U. D., and Jesse R. (2011). Psilocybin-occasioned mystical-type experiences: immediate and persisting dose-related effects. Psychopharmacology 218, 649-665. doi: 10.1007/s00213-011-2358-5
MacLean, K. A., Johnson, M. W., & Griffiths, R. R. (2011). Mystical experiences occasioned by the hallucinogen psilocybin lead to increases in the personality domain of openness. Journal of Psychopharmacology, 25(11), 1453-1461. doi:10.1177/0269881111420188
Piotrowski, N. A. (2013). Hallucinogens. Salem Press Encyclopedia Of Science